Times to be announced.
| Date | Time | At | Opponent | Location | Result |
|---|---|---|---|---|---|
| Sat, Sep 4, 2021 | 7:30 PM SEC Network | Home | Florida Atlantic Owls | Gainesville, FL | W, 35-14 |
| Sat, Sep 11, 2021 | 1:00 PM ABC | Away | USF Bulls | Tampa, FL | W, 42-20 |
| Sat, Sep 18, 2021 | 3:30 PM CBS | Home | Alabama Crimson Tide | Gainesville, FL | L, 31-29 |
| Sat, Sep 25, 2021 | 7:00 PM ESPN | Home | Tennessee Volunteers | Gainesville, FL | W, 38-24 |
| Sat, Oct 2, 2021 | 6:00 PM ESPN | Away | Kentucky Widcats | Lexington, KY | L, 20-13 |
| Sat, Oct 9, 2021 | 12:00 PM SEC Network | Home | Vanderbilt Commodores | Gainesville, FL | W, 42-0 |
| Sat, Oct 16, 2021 | Time TBA ET TV TBA | Away | LSU Tigers | Baton Rouge, LA | L, 49-42 |
| Sat, Oct 23, 2021 | OPEN | ||||
| Sat, Oct 30, 2021 | 3:30 PM CBS | Home | Georgia Bulldogs | Jacksonville, FL | |
| Sat, Nov 6, 2021 | 7:30 PM SEC Network | Away | South Carolina Gamecocks | Columbia, SC | |
| Sat, Nov 13, 2021 | 12:00 PM SEC Network | Home | Samford Bulldogs | Gainesville, FL | |
| Sat, Nov 20, 2021 | Time TBA ET TV TBA | Away | Missouri Tigers | Columbia, MO | |
| Sat, Nov 27, 2021 | Time TBA ET TV TBA | Home | Florida State Seminoles | Gainesville, FL | |
| Sat, Dec 4, 2021 | Time TBA ET TV TBA | SEC Championship | Atlanta, GA | ||
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